Leukocyte Adhesion Deficiency Induced Autoimmune Syndrome or L.A.D.I.A.S. is thought to be caused by poorly regulated immune system function. Specifically, increased levels of superoxides in the blood and/or increased levels of pro-inflammatory cytokines may be possible contributors or root causes of the disorder.
The syndrome manifests itself through largely uncontrolled inflammatory events in muscles, tendons and joints. L.A.D.I.A.S. is not currently understood and is not being professionally studied. This patient is the only documented case, so far.
Events or flare-ups seem to develop seasonally but also occasionally occur without warning and may be precipitated by a minor injury or impact. They can last anywhere from a few days to 2-3 weeks before resolving.
Traditional anti-inflammatory treatments are not an option to due the fact that anti-inflammatories are contraindicated in L.A.D. patients. To date, the traditional rest, ice, compression and elevation treatment protocol has been used, with limited success.
The following images document two L.A.D.I.A.S. events.